In endothelial cells and mouse retina, CD93 was found to be expressed in endothelial filopodia and to promote filopodia formation. Here, we demonstrate that CD93 regulates β 1 integrin signaling and organization of fibronectin fibrillogenesis during tumor vascularization. CD93 is a transmembrane receptor that is upregulated in tumor vessels in many cancers, including high-grade glioma. Tumor angiogenesis occurs through regulation of genes that orchestrate endothelial sprouting and vessel maturation, including deposition of a vessel-associated extracellular matrix.
1Department of Immunology, Genetics and Pathology, Science for Life Laboratory, Uppsala University, Rudbeck Laboratory, Uppsala, Sweden.ĢCentre for Research and Development, Uppsala University, Gävle Hospital, Gävle, Sweden.ģDepartment of Radiation Sciences and Oncology, Umeå University Hospital, Umeå, Sweden.ĤDepartment of Neuroscience, Neurology, Uppsala University, Uppsala, Sweden.ĥInstitute of Neuroscience and Physiology, Department of Clinical Neuroscience, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.ĦDepartment of Medical Biochemistry and Microbiology, Uppsala University, Uppsala, Sweden.ħVascular Biology Unit, FIRC Institute of Molecular Oncology, Milan, Italy.Īddress correspondence to: Anna Dimberg, Department of Immunology, Genetics and Pathology, Rudbeck Laboratory, Uppsala University, SE-751 85 Uppsala, Sweden.
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